Lakshmi S, Jayakrishnan A
Polymer Chemistry Division, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, India.
Artif Organs. 1998 Mar;22(3):222-9. doi: 10.1046/j.1525-1594.1998.06124.x.
Plasticized polyvinyl chloride (PVC), although not a blood-compatible polymer, is the material of choice for the manufacture of blood bags and hemodialysis tubing throughout the world. PVC is usually plasticized with di-(2-ethylhexyl phthalate) (DEHP) to impart flexibility and low temperature properties to the final product. DEHP belongs to a class of agents called hypolipidemic hepatocarcinogens, and it migrates in small quantities into the storage medium such as blood, plasma, or serum, resulting in a number of toxic effects. It has been shown that the migration resistance and blood compatibility of flexible PVC could be significantly improved by grafting polyethylene glycol (PEG), the most blood-compatible polymer known today, onto the surface of flexible PVC by the classical Williamson ether synthesis reaction. The technique is simple and versatile enough to produce blood-compatible, migration resistant PVC surfaces for many medical applications. The method may also find use for preventing plasticizer migration from PVC cling films and polyvinylidene chloride films used extensively in food packaging.
增塑聚氯乙烯（PVC）虽然不是一种血液相容性聚合物，但却是全球制造血袋和血液透析管路的首选材料。PVC通常用邻苯二甲酸二（2-乙基己基）酯（DEHP）增塑，以使最终产品具有柔韧性和低温性能。DEHP属于一类称为降血脂性肝癌致癌物的物质，它会少量迁移到血液、血浆或血清等储存介质中，从而产生多种毒性作用。研究表明，通过经典的威廉姆森醚合成反应将当今已知血液相容性最强的聚合物聚乙二醇（PEG）接枝到软质PVC表面，可以显著提高软质PVC的抗迁移性和血液相容性。该技术简单且用途广泛，足以生产出适用于多种医疗应用的血液相容性、抗迁移性PVC表面。该方法还可用于防止增塑剂从广泛用于食品包装的PVC保鲜膜和聚偏二氯乙烯薄膜中迁移。
