Marrinan E M, LaBrie R A, Mulliken J B
Department of Medicine, Children's Hospital/Harvard Medical School, Boston, Massachusetts 02115, USA.
Cleft Palate Craniofac J. 1998 Mar;35(2):95-100. doi: 10.1597/1545-1569_1998_035_0095_vfincp_2.3.co_2.
The goal of this study was to determine the relative importance of surgical technique, age at repair, and cleft type for velopharyngeal function.
This was a retrospective study of patients operated on by two surgeons using different techniques (von Langenbeck and Veau-Wardill-Kilner [VY]) at Children's Hospital, Boston, MA.
We included 228 patients who were at least 4 years of age at the time of review. Patients with identifiable syndromes, nonsyndromic Robin sequence, central nervous system disorders, communicatively significant hearing loss, and inadequate speech data were excluded.
Need for a pharyngeal flap was the measure of outcome.
Pharyngeal flap was necessary in 14% of von Langenbeck and 15% of VY repaired patients. There was a significant linear association (p = .025) between age at repair and velopharyngeal insufficiency (VPI). Patients with an attached vomer, soft cleft palate (SCP), and unilateral cleft lip/palate (UCLP) had a 10% flap rate, whereas those with an unattached vomer, hard/soft cleft palate (HSCP), and bilateral cleft lip/palate (BCLP) had a 23% flap rate (p = .03). Age at repair was critical for the unattached-vomer group (p = .03) but was not statistically significant for the attached-vomer group (p = .52).
Surgical technique was not a significant variable either in aggregate or for the Veau types. Patients in the earliest repair group (8-10 months) were the least likely to require a pharyngeal flap. Early repair was more critical for HSCP and BCLP patients. There was no correlation between velopharyngeal insufficiency and Veau hierarchy. The attached vomer/levator muscle complex may be a more important predictor of surgical success than the anatomic extent of cleft.
本研究的目的是确定手术技术、修复时年龄和腭裂类型对腭咽功能的相对重要性。
这是一项对马萨诸塞州波士顿儿童医院由两位外科医生采用不同技术(冯·朗根贝克法和沃-韦-基法[VY])进行手术的患者的回顾性研究。
我们纳入了228名在复查时至少4岁的患者。排除患有可识别综合征、非综合征性罗宾序列、中枢神经系统疾病、有显著交流意义的听力损失以及言语数据不充分的患者。
是否需要咽瓣作为结局指标。
冯·朗根贝克法修复的患者中有14%需要咽瓣,VY法修复的患者中有15%需要咽瓣。修复时年龄与腭咽闭合不全(VPI)之间存在显著的线性关联(p = 0.025)。有附着犁骨、软腭裂(SCP)和单侧唇腭裂(UCLP)的患者咽瓣使用率为10%,而有未附着犁骨、硬/软腭裂(HSCP)和双侧唇腭裂(BCLP)的患者咽瓣使用率为23%(p = 0.03)。修复时年龄对未附着犁骨组至关重要(p = 0.03),但对附着犁骨组无统计学意义(p = 0.52)。
总体而言,手术技术不是一个显著变量,对沃法类型而言也不是。最早修复组(8 - 10个月)的患者最不可能需要咽瓣。早期修复对HSCP和BCLP患者更为关键。腭咽闭合不全与沃氏分级之间无相关性。附着犁骨/提肌复合体可能比腭裂的解剖范围更能预测手术成功。