Jarema M, Choma M, Poniatowska R, Krawczyk R, Kozłowski P
Zakład Neuroradiologii IPiN w Warszawie.
Psychiatr Pol. 1997 Jan-Feb;31(1):21-32.
In 40 schizophrenic patients, various criteria of clinical improvement after neuroleptic treatment were compared in order to establish correlations between improvement after treatment and some clinical and MRI parameters. Three ways of evaluation of clinical improvement (CGI scale, PANSS index, percentage of improvement) correlated strongly with one another. Only the distribution of numbers of patients with different clinical improvement evaluated by the use of PANSS index was not statistically significant. Clinical improvement, evaluated with all three methods, significantly correlated with basal PANSS score as well as with the severity of positive symptoms and affective blunting, but not with the severity of schizophrenia negative symptoms. Only clinical improvement with the use of CGI demonstrated significantly better improvement in patients who had good previous response to neuroleptics. This particular method of clinical improvement evaluation, in contrast to other two methods, failed to reveal better response to neuroleptics among patients with no cortical atrophy found in MRI. Among patients with different improvement after treatment, evaluated with the use of all three methods, selected MRI parameters did not show significant differences with the exception of CGI improvement which correlated positively with the intensity of signal in T2-weighted image of gray matter in left medial frontal gyrus.
在40例精神分裂症患者中，比较了抗精神病药物治疗后临床改善的各种标准，以确定治疗后改善与一些临床和MRI参数之间的相关性。三种临床改善评估方法（CGI量表、PANSS指数、改善百分比）之间高度相关。仅使用PANSS指数评估的不同临床改善患者数量分布无统计学意义。用这三种方法评估的临床改善与基础PANSS评分以及阳性症状和情感迟钝的严重程度显著相关，但与精神分裂症阴性症状的严重程度无关。仅使用CGI评估的临床改善显示，既往对抗精神病药物反应良好的患者改善明显更好。与其他两种方法相比，这种特定的临床改善评估方法未能在MRI未发现皮质萎缩的患者中显示出对抗精神病药物的更好反应。在使用这三种方法评估的治疗后改善不同的患者中，除了CGI改善与左侧额内侧回灰质T2加权图像中的信号强度呈正相关外，所选的MRI参数没有显示出显著差异。
