Jarema M, Choma M, Krawczyk R, Poniatowska E, Kozłowski P
III Klinika Psychiatryczna IPiN, Warszawa.
Psychiatr Pol. 1997 Jan-Feb;31(1):33-46.
In forty schizophrenic (or schizophreniform disorder) patients diagnosed according to DSM-IV, the magnetic resonance imaging was performed. The T2 relaxation time was measured in selected brain regions from the dorsolateral prefrontal cortex as well as in amygdala. These results were compared with clinical parameters regarding severity of psychopathology and improvement after neuroleptic treatment. The mean T2 values of grey matter of right inferior frontal gyrus were significantly higher in patients with schizophreniform disorders (those patients were clinically diagnosed as suffering from cycloid psychoses) than in other types of schizophrenia. The T2 values of this region correlated inversely with the severity of negative symptoms before treatment. The T2 values of gray matter of left inferior frontal gyrus correlated positively with the severity of schizophrenic symptoms before treatment. Mean T2 values of left amygdala were significantly higher in patients showing less favorable improvement after neuroleptic treatment in comparison to those who improved better. No correlation was found between the presence of brain atrophy and T2 values in brain regions studied. The results allow to suggest that the measurement of T2 relaxation time might reveal interesting relations between clinical picture and neuroradiologic findings in schizophrenia, however clinical significance of such parameters still requires further elaboration.
对40名根据《精神疾病诊断与统计手册》第四版（DSM-IV）诊断为精神分裂症（或精神分裂症样障碍）的患者进行了磁共振成像检查。在背外侧前额叶皮层以及杏仁核的选定脑区测量了T2弛豫时间。将这些结果与精神病理学严重程度和抗精神病药物治疗后的改善情况等临床参数进行了比较。精神分裂症样障碍患者（这些患者临床诊断为患循环性精神病）右侧额下回灰质的平均T2值显著高于其他类型的精神分裂症患者。该区域的T2值与治疗前阴性症状的严重程度呈负相关。左侧额下回灰质的T2值与治疗前精神分裂症症状的严重程度呈正相关。与改善较好的患者相比，抗精神病药物治疗后改善较差的患者左侧杏仁核的平均T2值显著更高。在所研究的脑区中，未发现脑萎缩与T2值之间存在相关性。结果表明，T2弛豫时间的测量可能揭示精神分裂症临床症状与神经放射学结果之间的有趣关系，然而这些参数的临床意义仍需进一步阐述。
