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TXU（抗CD7）-商陆抗病毒蛋白作为一种有效的人类免疫缺陷病毒抑制剂。

TXU (anti-CD7)-pokeweed antiviral protein as a potent inhibitor of human immunodeficiency virus.

作者信息

Uckun F M, Chelstrom L M, Tuel-Ahlgren L, Dibirdik I, Irvin J D, Langlie M C, Myers D E

机构信息

Wayne Hughes Institute, St. Paul, Minnesota 55113, USA.

出版信息

Antimicrob Agents Chemother. 1998 Feb;42(2):383-8. doi: 10.1128/AAC.42.2.383.

DOI:10.1128/AAC.42.2.383
PMID:9527790
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC105418/
Abstract

We have evaluated the clinical potential of TXU (anti-CD7)-pokeweed antiviral protein (PAP) immunoconjugate (TXU-PAP) as a new biotherapeutic anti-human immunodeficiency virus (anti-HIV) agent by evaluating its anti-HIV type 1 (anti-HIV-1) activity in vitro, as well as in a surrogate human peripheral blood lymphocyte-severe combined immunodeficient (Hu-PBL-SCID) mouse model of human AIDS. The present report documents in a side-by-side comparison the superior in vitro anti-HIV-1 activity of TXU-PAP compared to the activities of zidovudine, 2',3'-didehydro-2',3'-dideoxythymidine, unconjugated PAP, and B53-PAP, an anti-CD4-PAP immunoconjugate. Notably, TXU-PAP elicited potent anti-HIV activity in the Hu-PBL-SCID mouse model of human AIDS without any side effects and at doses that were very well tolerated by cynomolgus monkeys. Furthermore, plasma samples from TXU-PAP-treated cynomolgus monkeys showed potent anti-HIV-1 activity in vitro.

摘要

我们通过评估TXU（抗CD7）-商陆抗病毒蛋白（PAP）免疫缀合物（TXU-PAP）在体外以及在人类艾滋病替代模型——人外周血淋巴细胞-严重联合免疫缺陷（Hu-PBL-SCID）小鼠模型中的抗1型人类免疫缺陷病毒（抗HIV-1）活性，来评估其作为一种新型生物治疗抗人类免疫缺陷病毒（抗HIV）药物的临床潜力。本报告通过并列比较记录了TXU-PAP相较于齐多夫定、2'，3'-二脱氢-2'，3'-二脱氧胸苷、未缀合的PAP以及一种抗CD4-PAP免疫缀合物B53-PAP在体外具有更优的抗HIV-1活性。值得注意的是，TXU-PAP在人类艾滋病的Hu-PBL-SCID小鼠模型中引发了强大的抗HIV活性，且无任何副作用，其剂量也能被食蟹猴很好地耐受。此外，来自接受TXU-PAP治疗的食蟹猴的血浆样本在体外显示出强大的抗HIV-1活性。

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本文引用的文献

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In vivo toxicity, pharmacokinetics, and antileukemic activity of TXU (anti-CD7)-pokeweed antiviral protein immunotoxin.TXU（抗CD7）-商陆抗病毒蛋白免疫毒素的体内毒性、药代动力学及抗白血病活性
Clin Cancer Res. 1997 Jun;3(6):881-90.
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Large scale manufacturing of TXU(anti-CD7)-pokeweed antiviral protein (PAP) immunoconjugate for clinical trials.用于临床试验的TXU（抗CD7）-商陆抗病毒蛋白（PAP）免疫偶联物的大规模生产。
Leuk Lymphoma. 1997 Oct;27(3-4):275-302. doi: 10.3109/10428199709059683.
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Anti-human immunodeficiency virus type 1 activity of an anti-CD4 immunoconjugate containing pokeweed antiviral protein.含商陆抗病毒蛋白的抗CD4免疫偶联物的抗1型人类免疫缺陷病毒活性
Antimicrob Agents Chemother. 1993 Apr;37(4):835-8. doi: 10.1128/AAC.37.4.835.
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DNA amplification for direct detection of HIV-1 in DNA of peripheral blood mononuclear cells.用于直接检测外周血单个核细胞DNA中HIV-1的DNA扩增。
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