作为手术预防用药给药后血浆和组织中培氟沙星的浓度。
Concentrations of pefloxacin in plasma and tissue after administration as surgical prophylaxis.
作者信息
Jacoberger B, Ubeaud G, Freys G, Pottecher T, Jung L, Koffel J C
机构信息
Department of Pharmacy, University Hospital Hautepierre, Strasbourg, France.
出版信息
Antimicrob Agents Chemother. 1998 Feb;42(2):425-7. doi: 10.1128/AAC.42.2.425.
Plasma and epiploic-fat drug concentrations determined by high-performance liquid chromatography and fat penetration of pefloxacin and its metabolite (norfloxacin) given for antimicrobial prophylaxis were studied in patients scheduled for colorectal surgery. Concentrations of pefloxacin in plasma decreased about 40% from the beginning of the operation to closure of the peritoneum, and corresponding levels in epiploic fat stayed stable. The plasma and tissue norfloxacin concentrations were very low. Concentrations of pefloxacin in tissue were greater than MIC at which 90% of isolates are inhibited for sensitive bacteria (members of the family Enterobacteriaceae). The penetration of pefloxacin into epiploic fat was about 32%.
我们对计划进行结肠直肠手术的患者，研究了通过高效液相色谱法测定的血浆和网膜脂肪中的药物浓度，以及给予预防性抗菌治疗的培氟沙星及其代谢产物（诺氟沙星）的脂肪渗透情况。从手术开始到腹膜关闭，血浆中培氟沙星的浓度下降了约40%，而网膜脂肪中的相应水平保持稳定。血浆和组织中的诺氟沙星浓度非常低。对于敏感细菌（肠杆菌科成员），组织中培氟沙星的浓度高于能抑制90%分离株的最低抑菌浓度。培氟沙星进入网膜脂肪的渗透率约为32%。
Zotero 插件