培氟沙星在人心脏瓣膜中的渗透情况。

Penetration of pefloxacin in human heart valves.

作者信息

Brion N, Lessana A, Mosset F, Lefevre J J, Montay G

出版信息

J Antimicrob Chemother. 1986 Apr;17 Suppl B:89-92. doi: 10.1093/jac/17.suppl_b.89.

DOI:10.1093/jac/17.suppl_b.89

Abstract

Pefloxacin concentrations were measured by HPLC in serum, subcutaneous tissue, heart muscle and heart valves of 41 patients receiving a one hour infusion of 800 mg iv 4, 8, 12, 18, or 24 h before open heart surgery for prosthetic cardiac valve insertion. In all but three of the 46 valvular samples, pefloxacin concentrations were higher than the mode MIC of Staphylococcus, Enterobacteriaceae and Pseudomonas microorganisms causing infections following open heart surgery. Pefloxacin therefore has good penetration of heart valves and is present for up to 24 h. It could be considered as a useful drug in the prophylaxis of cardiac surgery and in therapy of bacterial endocarditis due to susceptible micro-organisms.

摘要

在41例接受800毫克静脉注射1小时的患者中，于心脏直视手术植入人工心脏瓣膜前4、8、12、18或24小时，通过高效液相色谱法测定血清、皮下组织、心肌和心脏瓣膜中的培氟沙星浓度。在46个瓣膜样本中，除3个样本外，培氟沙星浓度均高于心脏直视手术后引起感染的葡萄球菌、肠杆菌科和假单胞菌微生物的众数最低抑菌浓度。因此，培氟沙星对心脏瓣膜具有良好的穿透性，且可存在长达24小时。它可被视为预防心脏手术和治疗由易感微生物引起的细菌性心内膜炎的一种有用药物。