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5-氯吡嗪酰胺的体外抗分枝杆菌活性

In vitro antimycobacterial activity of 5-chloropyrazinamide.

作者信息

Cynamon M H, Speirs R J, Welch J T

机构信息

Veterans Affairs Medical Center, Syracuse, New York 13210, USA.

出版信息

Antimicrob Agents Chemother. 1998 Feb;42(2):462-3. doi: 10.1128/AAC.42.2.462.

DOI:10.1128/AAC.42.2.462
PMID:9527809
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC105437/
Abstract

5-Chloropyrazinamide and 5-chloropyrazinoic acid were evaluated for in vitro activity against Mycobacterium tuberculosis, Mycobacterium bovis, and several nontuberculous mycobacteria by a broth dilution method. 5-Chloropyrazinamide was more active than pyrazinamide against all organisms tested. It is likely that this agent has a different mechanism of action than pyrazinamide.

摘要

采用肉汤稀释法评估了5-氯吡嗪酰胺和5-氯吡嗪酸对结核分枝杆菌、牛分枝杆菌以及几种非结核分枝杆菌的体外活性。5-氯吡嗪酰胺对所有测试菌株的活性均高于吡嗪酰胺。该药物的作用机制可能与吡嗪酰胺不同。

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本文引用的文献

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