肠外营养会改变家兔血清磷脂的脂肪酸组成。
Parenteral feeding alters the fatty acid composition of serum phospholipids of rabbits.
作者信息
Moss R L, Enomoto T M, Haynes A, Fry D E, Glew R H
机构信息
Department of Surgery, Stanford University School of Medicine, Palo Alto, California, USA.
出版信息
JPEN J Parenter Enteral Nutr. 1998 Mar-Apr;22(2):98-101. doi: 10.1177/014860719802200298.
BACKGROUND
Cholestatic liver disease develops in 30% to 70% of neonates receiving total parental nutrition (TPN). We analyzed the fatty acid composition of serum phospholipids from control and TPN-fed rabbits to determine if TPN altered the fatty acid profile.
METHODS
Eleven male New Zealand White rabbits aged 9 to 11 weeks received TPN, whereas 11 other rabbits were offered standard laboratory rabbit chow ad libitum. After 14 days on the prescribed diet, serum samples were analyzed for their phospholipid fatty acid content by gas chromatography.
RESULTS
The proportions of palmitolenic (16:2n7), alpha-linolenic (18:3n3), arachidic (20:0), and eicosaenoic (20:1n9) acids were significantly lower in the serum phospholipids of the TPN-fed animals compared with the control group. The proportion of docosahexaenoic acid (22:6n3), a fatty acid that is critical to the development of the nervous system, was increased two- to threefold.
CONCLUSIONS
The differences in proportions of fatty acids observed between control and TPN-fed animals indicate that a fatty acid elongation and desaturation pathways are perturbed in rabbits on TPN.
背景
接受全肠外营养（TPN）的新生儿中，30%至70%会发生胆汁淤积性肝病。我们分析了对照组和接受TPN喂养的兔子血清磷脂的脂肪酸组成，以确定TPN是否改变了脂肪酸谱。
方法
11只9至11周龄的雄性新西兰白兔接受TPN，另外11只兔子随意喂食标准实验室兔粮。在规定饮食14天后，通过气相色谱法分析血清样本的磷脂脂肪酸含量。
结果
与对照组相比，接受TPN喂养的动物血清磷脂中棕榈油酸（16:2n7）、α-亚麻酸（18:3n3）、花生酸（20:0）和二十碳烯酸（20:1n9）的比例显著降低。对神经系统发育至关重要的脂肪酸二十二碳六烯酸（22:6n3）的比例增加了两到三倍。
结论
对照组和接受TPN喂养的动物之间观察到的脂肪酸比例差异表明，接受TPN的兔子的脂肪酸延长和去饱和途径受到干扰。
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