重瓣环肽，一种从真菌卷边齿菌和白卷边齿菌中分离得到的新型细胞毒性双环氧化物。

Repandiol, a new cytotoxic diepoxide from the mushrooms Hydnum repandum and H. repandum var. album.

作者信息

Takahashi A, Endo T, Nozoe S

机构信息

Faculty of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.

出版信息

Chem Pharm Bull (Tokyo). 1992 Dec;40(12):3181-4. doi: 10.1248/cpb.40.3181.

DOI:10.1248/cpb.40.3181

PMID:1294319

Abstract

Repandiol, a new cytotoxic diepoxide has been isolated from the mushrooms Hydnum repandum and H. repandum var. album. The chemical structure was elucidated as (2R,3R,8R,9R)-4,6-decadiyne-2,3:8,9-diepoxy-1,10-diol on the basis of spectroscopic analysis. The structure was confirmed by the synthesis of optically active repandiol. Repandiol displayed potent cytotoxic activity against various tumor cells.

摘要

从齿菌（Hydnum repandum）和白色齿菌（H. repandum var. album）中分离出一种新的具有细胞毒性的双环氧化物——重齿二醇。通过光谱分析，其化学结构被确认为(2R,3R,8R,9R)-4,6-癸二炔-2,3:8,9-二环氧-1,10-二醇。通过旋光性重齿二醇的合成对该结构进行了确认。重齿二醇对多种肿瘤细胞显示出强大的细胞毒性活性。