Mischke R, Pöhle D, Schoon H A, Fehr M, Nolte I
Klinik für kleine Haustiere der Tierärztlichen Hochschule Hannover.
Dtsch Tierarztl Wochenschr. 1998 Feb;105(2):43-7.
In seven dogs with histologically proven liver cirrhosis the activity of the single coagulation factors with the exception of factor VIII:C, of the inhibitors antithrombin III and protein C as well as plasminogen and alpha 2-antiplasmin was distinctly lower than in the control group (p < 0.0001). The changes of the factors VII [median (x0.50) = 17 %] and X (x0.50 = 18 %) as well as of protein C (x0.50 = 15 %) were particularly pronounced. Diminution of activity certainly exceeded also in nearly all of the remaining haemostatic proteins the decrease of albumin concentration. Besides the shorter half life time, this reflected an increased consumption in consequence of intravascular coagulations and fibrinolysis. The latter could also be seen from the significantly increased concentrations of soluble fibrin and fibrin(ogen) degradation products. Therefore, the alterations of the haemostatic system measured in dogs in many details were in accordance with findings in human beings suffering from liver cirrhosis.
在七只经组织学证实患有肝硬化的狗中，除因子VIII:C外，单一凝血因子、抗凝血酶III和蛋白C抑制剂以及纤溶酶原和α2-抗纤溶酶的活性明显低于对照组（p < 0.0001）。因子VII[中位数（x0.50）= 17%]和X（x0.50 = 18%）以及蛋白C（x0.50 = 15%）的变化尤为明显。几乎所有其余止血蛋白的活性降低肯定也超过了白蛋白浓度的下降。除了半衰期较短外，这反映了由于血管内凝血和纤维蛋白溶解导致的消耗增加。后者也可以从可溶性纤维蛋白和纤维蛋白（原）降解产物浓度的显著增加中看出。因此，在狗身上测量到的止血系统变化在许多细节上与肝硬化患者的研究结果一致。
