BRCA1和BRCA2基因的功能。
Functions of the BRCA1 and BRCA2 genes.
作者信息
Bertwistle D, Ashworth A
机构信息
CRC Centre for Cell and Molecular Biology, Chester Beatty Laboratories, Institute of Cancer Research, London, UK.
出版信息
Curr Opin Genet Dev. 1998 Feb;8(1):14-20. doi: 10.1016/s0959-437x(98)80056-7.
PMID:9529600
Abstract
Mutations in the BRCA1 and BRCA2 genes confer a high risk of breast cancer development. Both genes encode very large proteins of unknown function but recent results suggest that they may have roles in transcriptional regulation and DNA repair. These advances offer the prospect of understanding not only the normal cellular function of these genes but also how their loss leads to tumour formation.
摘要
BRCA1和BRCA2基因的突变会导致乳腺癌发生的高风险。这两个基因都编码功能未知的非常大的蛋白质，但最近的研究结果表明，它们可能在转录调控和DNA修复中发挥作用。这些进展不仅为了解这些基因的正常细胞功能，也为了解它们的缺失如何导致肿瘤形成提供了前景。
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