Lloyd A C
MRC Laboratory for Molecular Cell Biology, University College London, London, UK.
Curr Opin Genet Dev. 1998 Feb;8(1):43-8. doi: 10.1016/s0959-437x(98)80060-9.
In the past year, complex interactions between Ras and the cell cycle have been identified. In primary cells, activated Ras induces a cell-cycle arrest via the induction of cyclin-dependent kinase inhibitors (CDKIs). Oncogenic changes that cooperate with Ras act by neutralising CDKIs by various mechanisms. In the absence of a negative growth signal from Ras, such as in most immortalised cell lines, Ras acts positively on the cell cycle. Insights have been made into the mechanisms by which Ras abrogates remaining cell-cycle controls.
在过去的一年里，人们发现了Ras与细胞周期之间复杂的相互作用。在原代细胞中，活化的Ras通过诱导细胞周期蛋白依赖性激酶抑制剂（CDKIs）来诱导细胞周期停滞。与Ras协同作用的致癌性变化通过各种机制中和CDKIs来发挥作用。在没有来自Ras的负生长信号的情况下，例如在大多数永生化细胞系中，Ras对细胞周期起正向作用。人们已经深入了解了Ras消除剩余细胞周期控制的机制。
