Frame S, Balmain A
Division of Signal Transduction Therapy, Department of Biochemistry, MSI/WTB complex, University of Dundee, Dundee, DD1 5EH, Scotland.
Curr Opin Genet Dev. 2000 Feb;10(1):106-13. doi: 10.1016/s0959-437x(99)00052-0.
Expression of RAS proteins can have either positive or negative effects on cell growth, differentiation and death. New technologies are being developed for the generation of animal models to address the questions of where, when and how much Ras is expressed during tumorigenesis, and how these disparate signals are integrated during multistage carcinogenesis.
RAS蛋白的表达对细胞生长、分化和死亡可能产生正面或负面影响。目前正在开发新技术以生成动物模型，从而解决在肿瘤发生过程中Ras在何处、何时以及表达量多少的问题，以及在多阶段致癌过程中这些不同信号是如何整合的。
