发育与癌症中的patched基因

The patched gene in development and cancer.

作者信息

Ingham P W

机构信息

Developmental Genetics Programme, Krebs Institute, University of Sheffield, UK.

出版信息

Curr Opin Genet Dev. 1998 Feb;8(1):88-94. doi: 10.1016/s0959-437x(98)80067-1.

DOI:10.1016/s0959-437x(98)80067-1

PMID:9529611

Abstract

The cloning of vertebrate homologues of the Drosophila segment polarity gene patched has led to confirmation of a role for the multipass transmembrane protein which it encodes as a receptor for secreted signalling proteins of the Hedgehog family. In addition, human patched has been identified as a tumour suppressor gene implicated in basal cell carcinomas and medullablastomas.

摘要

果蝇节段极性基因patched的脊椎动物同源物的克隆，证实了它所编码的多次跨膜蛋白作为刺猬家族分泌信号蛋白受体的作用。此外，人类patched已被鉴定为一种与基底细胞癌和髓母细胞瘤有关的肿瘤抑制基因。