Jones N L, Sherman P M
Division of Gastroenterology and Nutrition, Hospital for Sick Children, Toronto, Canada.
Curr Opin Pediatr. 1998 Feb;10(1):19-23. doi: 10.1097/00008480-199802000-00005.
Helicobacter pylori causes chronic gastritis and peptic ulcer disease and is epidemiologically associated with the subsequent development of gastric malignancies. Knowledge regarding H. pylori is of particular relevance to pediatricians since acquisition of the infection occurs mainly during the childhood years and may be associated with the development of more severe disease manifestations such as gastric malignancies. Because only a minority of infected individuals will ever develop the sequelae of peptic ulcer disease or gastric cancer, the identification of bacteria factors that play a role in disease pathophysiology is a major focus of current research. This review highlights recent advances in our knowledge of disease pathogenesis, with particular emphasis on bacterial virulence. In addition, the recent literature addressing epidemiology, transmission, clinical features, treatment, and prevention of H. pylori infection is reviewed.
幽门螺杆菌可引发慢性胃炎和消化性溃疡疾病，在流行病学上与随后发生的胃部恶性肿瘤相关。由于幽门螺杆菌感染主要发生在儿童时期，且可能与更严重的疾病表现（如胃部恶性肿瘤）的发展相关，因此有关幽门螺杆菌的知识对儿科医生尤为重要。由于只有少数受感染个体最终会出现消化性溃疡疾病或胃癌的后遗症，确定在疾病病理生理学中起作用的细菌因素是当前研究的主要重点。本综述重点介绍了我们在疾病发病机制方面的最新进展，特别强调细菌毒力。此外，还综述了近期关于幽门螺杆菌感染的流行病学、传播、临床特征、治疗和预防的文献。
