Lee Jin Uk, Jung Kwonil, Kim Okjin
Department of Laboratory Animal Science, College of Medicine, Seoul National University, Seoul 110-799, Korea.
J Vet Sci. 2006 Sep;7(3):225-8. doi: 10.4142/jvs.2006.7.3.225.
Helicobacter pylori (H. pylori) infection is acquired mainly in early childhood but the precise transmission routes are unclear. This study examined the maternal H. pylori infection status in order to determine the potential of perinatal transmission. These issues were investigated using an experimental murine model, the Mongolian gerbil, which has been reported to be the most suitable laboratory animal model for studying H. pylori. Pregnant Mongolian gerbils, infected experimentally with H. pylori, were divided into two groups. The stomachs of the mother and litters were isolated and assessed for the transmission of H. pylori at the prenatal period (2 weeks after pregnancy) and at the parturition day. The bacterial culture, polymerase chain reaction (PCR) and rapid urease test were used to examine the presence of the transmitted H. pylori. There was no H. pylori observed in any of the fetuses during pregnancy and in the litters at parturition. This suggests that vertical infection during the prenatal period or delivery procedure is unlikely to be route of mother-tochild transmission of a H. pylori infection.
幽门螺杆菌（H. pylori）感染主要在儿童早期获得，但确切的传播途径尚不清楚。本研究检测了母亲的幽门螺杆菌感染状况，以确定围产期传播的可能性。使用实验性小鼠模型蒙古沙鼠对这些问题进行了研究，据报道蒙古沙鼠是研究幽门螺杆菌最适合的实验动物模型。将经实验感染幽门螺杆菌的怀孕蒙古沙鼠分为两组。在孕期（怀孕2周后）和分娩日，分离母鼠及其幼崽的胃部，评估幽门螺杆菌的传播情况。采用细菌培养、聚合酶链反应（PCR）和快速尿素酶试验检测传播的幽门螺杆菌的存在情况。在孕期的任何胎儿以及分娩时的幼崽中均未观察到幽门螺杆菌。这表明孕期或分娩过程中的垂直感染不太可能是幽门螺杆菌母婴传播的途径。
