Akpolat I, Ozyilkan E, Karagöz F, Kandemyr B
Ondokuz Mayys University, School of Medicine, Department of Pathology, Samsun, Turkey.
Acta Gastroenterol Belg. 1997 Oct-Dec;60(4):251-4.
Hepatitis C virus (HCV) is the major cause of posttransfusion non-A, non-B hepatitis. The aim of this study is to describe the morphological changes related to HCV infection found in Turkey and compare the similarities and differences with the previous reports. Liver biopsies from 44 patients with HCV infection were studied. Chronic active hepatitis was the most common (56.8%) histopathological lesion. Most of the cases (n = 15, 34.1%) with chronic active hepatitis showed mild activity and mean HAI was 5.5 in these cases. The presence of sinusoidal lymphocytes (79.5%) and Kupffer cell proliferation (68.2%) were the most common histological features. We could not find any publication about histopathological characteristics of HCV infection from Turkey in MEDLINE database. This study shows that histopathological changes seen in patients with chronic HCV infection in Turkey is comparable with the literature, but more histopathological studies including genotyping of HCV and objective criteria to evaluate histopathological changes of chronic HCV infection are needed for definite conclusion.
丙型肝炎病毒（HCV）是输血后非甲非乙型肝炎的主要病因。本研究旨在描述在土耳其发现的与HCV感染相关的形态学变化，并与既往报告比较异同。对44例HCV感染患者的肝活检组织进行了研究。慢性活动性肝炎是最常见的（56.8%）组织病理学病变。大多数慢性活动性肝炎病例（n = 15，34.1%）表现为轻度活动，这些病例的平均HAI为5.5。窦状隙淋巴细胞浸润（79.5%）和库普弗细胞增殖（68.2%）是最常见的组织学特征。在MEDLINE数据库中，我们未找到关于土耳其HCV感染组织病理学特征的任何出版物。本研究表明，土耳其慢性HCV感染患者的组织病理学变化与文献报道具有可比性，但需要更多包括HCV基因分型以及评估慢性HCV感染组织病理学变化的客观标准的组织病理学研究才能得出明确结论。
