Rhee J K, Kim H C, Park B K
Bio-Safety Research Institute, Chonbuk National University, Chonju, Korea.
Korean J Parasitol. 1998 Mar;36(1):33-6. doi: 10.3347/kjp.1998.36.1.33.
Hemagglutinin (HA) titers to sRBC were chronologically observed in chickens orally inoculated at 2 days of age with 5 x 10(5) oocysts of Cryptosporidium baileyi. All the infected chickens exhibited negligible HA titers by 44 days postinoculation (PI). The titers were elevated as time progressed, and peaked on day 52 PI, declined gradually thereafter, and eventually reached to normal titers on day 92 PI. On the contrary, the titers in uninfected chickens were higher in comparison with infected chickens during the experiment. Chickens infected with the protozoa showed normal oocyst shedding profiles during this period. These data suggest that C. baileyi infection suppress development of humoral immunity to sRBC in chickens. It is possible that impairment of the bursa of Fabricius by cryptosporidiosis rendered chickens vulnerable to other pathogens.
对2日龄经口接种5×10⁵个贝氏隐孢子虫卵囊的鸡，按时间顺序观察其对绵羊红细胞（sRBC）的血凝素（HA）效价。所有感染鸡在接种后44天（PI）时HA效价可忽略不计。随着时间推移，效价升高，在接种后52天达到峰值，此后逐渐下降，并最终在接种后92天恢复到正常效价。相反，在实验期间，未感染鸡的效价相比感染鸡更高。感染原生动物的鸡在此期间显示出正常的卵囊排出情况。这些数据表明，贝氏隐孢子虫感染抑制了鸡对sRBC的体液免疫发育。隐孢子虫病导致法氏囊受损可能使鸡易受其他病原体感染。
