Rhee J K, Yang H J, Kim H C
Bio-Safety Research Institute, Veterinary School, Chonbuk National University, Chonju, Korea.
Korean J Parasitol. 1998 Dec;36(4):281-4. doi: 10.3347/kjp.1998.36.4.281.
Humoral immune response of young chicks to Brucella abortus strain 1119-3 inoculation was monitored to verify the degree of immunosuppression caused by infection with Cryptosporidium baileyi. Young chicks (2-day-old) were orally inoculated each with 2 x 10(6) oocysts of C. baileyi, and then injected intramuscularly with 0.3 ml B. abortus strain 1119-3 containing 1 x 10(9) living organisms on day 14 postinoculation (PI). Serum samples were tested by plate agglutination test on day 17 PI onwards at an interval of 3-6 days over a period of 36 days. Infected chicks with the coccidium showed significantly lower antibody titers than those of uninfected controls (P < 0.05). These findings document that C. baileyi infection in early life stage may predispose chicks easily to other potential poultry diseases.
监测雏鸡对牛流产布鲁氏菌1119-3株接种的体液免疫反应，以验证贝氏隐孢子虫感染所引起的免疫抑制程度。雏鸡（2日龄）每只口服接种2×10⁶个贝氏隐孢子虫卵囊，然后在接种后第14天（PI）肌肉注射0.3 ml含1×10⁹个活生物体的牛流产布鲁氏菌1119-3株。在接种后第17天起，每隔3 - 6天采集血清样本进行平板凝集试验，持续36天。感染球虫的雏鸡抗体滴度显著低于未感染对照雏鸡（P < 0.05）。这些研究结果证明，生命早期阶段的贝氏隐孢子虫感染可能使雏鸡更容易感染其他潜在的家禽疾病。
