Mochizuki F, Fujii M, Kasakura Y, Imai S, Kanamori N, Kasahara M, Yamagata M, Iwai S
3rd Dept. of Surgery, Nihon University School of Medicine.
Gan To Kagaku Ryoho. 1998 Mar;25(4):593-6.
Combination chemotherapy with 5-FU and CDDP was given to two patients with obstructive jaundice due to intra-abdominal lymph-node metastases of advanced and recurrent gastric cancer. One patient was a primary case associated with lymph-node metastases of portal fissure and periaorta, and the other was a recurrent case associated with lymph-node metastases of hepatoduodenal ligament and periaorta. The regimen consisted of 5-FU 1,000 mg/ m2 (day 1-5, continuous infusion) and CDDP 100 mg/m2 (day 3, 1 hr drip infusion). The interval was from the 6th to 21st day. The response to chemotherapy showed shrinking of intra-abdominal lymph-nodes and reopening of the biliary tract. The patients could be discharged from the hospital without PTBD tube and enjoyed a better quality of life (QOL). This therapy is thought to be effective against obstructive jaundice due to intra-abdominal lymph-node metastases of advanced and recurrent gastric cancer.
对两名因晚期复发性胃癌腹腔淋巴结转移导致梗阻性黄疸的患者进行了5-氟尿嘧啶（5-FU）和顺铂（CDDP）联合化疗。一名患者为原发性病例，伴有肝门裂和腹主动脉周围淋巴结转移，另一名为复发性病例，伴有肝十二指肠韧带和腹主动脉周围淋巴结转移。化疗方案为5-FU 1000mg/m²（第1 - 5天，持续输注）和顺铂100mg/m²（第3天，1小时滴注）。间隔为第6至21天。化疗反应显示腹腔淋巴结缩小，胆道重新开放。患者无需经皮经肝胆道引流（PTBD）管即可出院，生活质量（QOL）得到改善。该疗法被认为对晚期复发性胃癌腹腔淋巴结转移所致的梗阻性黄疸有效。
