Mochizuki F, Tomioka K, Mizuno Y, Sato F, Yamagata T, Nagakawa Y, Kobari Y, Fujii M, Iwai S, Tanaka T
Dept. of Surgery, Kobari General Hospital.
Gan To Kagaku Ryoho. 1995 Jan;22(1):115-8.
Combination chemotherapy with 5-FU and CDDP was given to two patients with far advanced gastric cancer. One patient was associated with metastases of lung, liver, pancreas and Virchow and periaortic lymph nodes, and the other was associated with metastases of periaortic lymph nodes and malignant ascitis. The regimen consisted of 5-FU 1,000 mg/m2 (day 1-5, continuous infusion) and CDDP 100 mg/m2 (day 3, 1 hr drip infusion). The interval was from the 6th to the 21st day. The response to chemotherapy showed shrinking of primary gastric lesions and metastases of liver, pancreas and periaortic lymph nodes, and disappearance of Virchow lymph nodes and malignant ascitis. Adverse reactions were thrombocytopenia (Grade 4), leukocytopenia (Grade 3), stomatitis (Grade 1, 3), vomiting (Grade 1, 2) and peripheral neuropathy (Grade 3). This therapy is thought to be effective against far advanced gastric cancer.
对两名晚期胃癌患者进行了5-氟尿嘧啶（5-FU）和顺铂（CDDP）联合化疗。一名患者伴有肺、肝、胰腺转移，以及魏尔啸淋巴结和主动脉旁淋巴结转移；另一名患者伴有主动脉旁淋巴结转移和恶性腹水。治疗方案为5-FU 1000 mg/m²（第1 - 5天，持续输注）和顺铂100 mg/m²（第3天，1小时滴注）。间隔时间为第6天至第21天。化疗反应显示原发性胃病变以及肝、胰腺和主动脉旁淋巴结转移灶缩小，魏尔啸淋巴结和恶性腹水消失。不良反应包括血小板减少（4级）、白细胞减少（3级）、口腔炎（1级、3级）、呕吐（1级、2级）和周围神经病变（3级）。该疗法被认为对晚期胃癌有效。
