Fukushima Y, Kawata Y, Onda T, Kitagawa M
Scientific Liaison Office, Nestlé Japan Ltd., Tokyo, Japan.
J Nutr Sci Vitaminol (Tokyo). 1997 Dec;43(6):673-8. doi: 10.3177/jnsv.43.673.
Food antigens transferred into breast milk sometimes cause an allergic reaction in exclusively breast-fed infants. This study will show whether the intake of a whey hydrolysate formula for lactating women (MOM HA) can reduce the appearance of food antigens in breast milk. Lactating women in the MOM group (n = 12) consumed MOM HA as a substitute for cow's milk and those in the COW group (n = 13) consumed cow's milk for more than 4 months. After the ingestion of 200 mL of MOM HA and cow's milk by the women in the MOM and COW groups, respectively, the first breast milk samples were obtained and beta-lactoglobulin was measured using enzyme-linked immunosorbent assay. The number of subjects with detectable beta-lactoglobulin (> 0.1 ng/mL) in the MOM group was two (17%), which was significantly less than that in the COW group (11 subjects, 85%, p < 0.01). The level of beta-lactoglobulin was also lower in the MOM group than the COW group (p < 0.01). Subsequently, the women in the MOM group consumed cow's milk and those in the COW group consumed MOM HA for one week; then a second sampling was performed. beta-Lactoglobulin was detected in three (25%) and 8 subjects (62%) in the MOM and COW groups, respectively. The level of beta-lactoglobulin was still lower in the MOM group (p < 0.05). The consumption of whey hydrolysate formula by lactating women over a considerable time reduces the transfer of beta-lactoglobulin into their breast milk, and the low level can be maintained even after inadvertent ingestion of cow's milk.
转移到母乳中的食物抗原有时会在纯母乳喂养的婴儿中引起过敏反应。本研究将表明，哺乳期妇女摄入乳清水解配方奶粉（MOM HA）是否可以减少母乳中食物抗原的出现。MOM组（n = 12）的哺乳期妇女食用MOM HA替代牛奶，COW组（n = 13）的哺乳期妇女食用牛奶超过4个月。MOM组和COW组的妇女分别摄入200 mL的MOM HA和牛奶后，采集首次母乳样本，使用酶联免疫吸附测定法测量β-乳球蛋白。MOM组中可检测到β-乳球蛋白（> 0.1 ng/mL）的受试者数量为2名（17%），显著少于COW组（11名受试者，85%，p < 0.01）。MOM组中β-乳球蛋白的水平也低于COW组（p < 0.01）。随后，MOM组的妇女食用牛奶，COW组的妇女食用MOM HA一周；然后进行第二次采样。MOM组和COW组分别有3名（25%）和8名（62%）受试者检测到β-乳球蛋白。MOM组中β-乳球蛋白的水平仍然较低（p < 0.05）。哺乳期妇女在相当长的时间内食用乳清水解配方奶粉可减少β-乳球蛋白向母乳中的转移，即使在意外摄入牛奶后，低水平也能维持。
