Eynard A R
Instituto de Biología Celular, Facultad de Ciencias Médicas, Córdoba, Argentina.
Nutrition. 1998 Feb;14(2):211-6. doi: 10.1016/s0899-9007(97)00426-7.
A considerable amount of experimental, clinical and epidemiological data indicate that dietary fats play a role in urinary tract tumorigenesis. In rodents, chronic essential fatty acid (EFA) deficiency seems to induce both urolithiasis and transitional hyperplasias, followed by a tendency for tumorigenesis of the urinary passages. High intake of saturated fats or non-EFAs, conditions that may induce EFA deficiency (EFAD) increase the risk of bladder cancer in case-control studies. In other cell populations, EFAs are beneficial as preventive and therapeutic nutrients for the treatment of cancer. Thus, it is reasonable to assume that abnormal metabolism and/or nutritional deprivation of EFA, by inducing a chronic or a subclinical EFA deficiency, may enhance the risk of urothelial tumorigenesis.
大量实验、临床和流行病学数据表明，膳食脂肪在尿路肿瘤发生过程中发挥作用。在啮齿动物中，慢性必需脂肪酸（EFA）缺乏似乎会诱发尿路结石和移行上皮增生，随后出现尿路肿瘤发生的倾向。在病例对照研究中，饱和脂肪或非必需脂肪酸的高摄入量（可能导致必需脂肪酸缺乏的情况）会增加患膀胱癌的风险。在其他细胞群体中，必需脂肪酸作为癌症治疗的预防和治疗性营养素是有益的。因此，有理由假设，必需脂肪酸的代谢异常和/或营养缺乏，通过诱发慢性或亚临床必需脂肪酸缺乏，可能会增加尿路上皮肿瘤发生的风险。
