Lee E H, Chen F, Chan J, Bose K
National University of Singapore, Republic of Singapore.
J Pediatr Orthop. 1998 Mar-Apr;18(2):155-60.
Chondrocytes were cultured from cartilage harvested from the iliac apophysis and knee joints of New Zealand White (NZW) rabbits. An experimental model for growth arrest was created by excising the medial half of the proximal growth plate of the tibia of 6-week-old NZW rabbits. The cultured chondrocytes were embedded in agarose and transferred into the growth-plate defect after excision of the physis. Transfer also was performed after excision of the bony bridge in established growth arrest. In both cases, growth arrest with angular deformation of the tibia was prevented. Histologic studies confirmed the viability of the chondrocytes in the new host physis.
从新西兰白兔（NZW）的髂骨骨骺和膝关节获取软骨，从中培养软骨细胞。通过切除6周龄NZW兔胫骨近端生长板的内侧一半，建立生长停滞的实验模型。将培养的软骨细胞包埋在琼脂糖中，在切除骨骺后转移至生长板缺损处。在已形成生长停滞的骨桥切除后也进行转移。在这两种情况下，均防止了胫骨的生长停滞伴角形畸形。组织学研究证实了软骨细胞在新的宿主骨骺中的活力。
