Janas M S, Arrøe M, Hansen S H, Graem N
Department of Pathology, Rigshospitalet, Denmark.
APMIS. 1998 Feb;106(2):300-4. doi: 10.1111/j.1699-0463.1998.tb01350.x.
Three cases of lung hypoplasia occurring in two siblings and in an unrelated child are reported. All three cases had been exposed to valproate in utero. The two female siblings had no other malformations, whereas the third female had a number of defects consistent with the fetal valproate syndrome. Thus, none of the known major causes of lung hypoplasia was present in any of the three cases. It is discussed whether pulmonary hypoplasia may be a separate disease entity, or caused by prenatal exposure to valproate.
报告了两例发生在兄弟姐妹中的肺发育不全病例以及一例发生在无血缘关系儿童中的肺发育不全病例。所有这三例病例在子宫内均接触过丙戊酸盐。这两名女性兄弟姐妹没有其他畸形，而第三名女性有一些与胎儿丙戊酸盐综合征相符的缺陷。因此，这三例病例中均不存在已知的肺发育不全的主要病因。文中讨论了肺发育不全是否可能是一种独立的疾病实体，或者是由产前接触丙戊酸盐引起的。
