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胎儿丙戊酸盐综合征

Fetal valproate syndrome.

作者信息

Kulkarni M L, Zaheeruddin M, Shenoy Nivedita, Vani H N

机构信息

Department of pediatrics, JJM Medical College, Davangere, Karnataka, India.

出版信息

Indian J Pediatr. 2006 Oct;73(10):937-9. doi: 10.1007/BF02859291.

DOI:10.1007/BF02859291
PMID:17090909
Abstract

Fetal Valproate Syndrome results from prenatal exposure to valproic acid. It is characterized by distinctive facial appearance, a cluster of minor and major anomalies and central nervous system dysfunction. Here we report a 4-year-old boy with typical facial features of Fetal Valproate Syndrome.

摘要

胎儿丙戊酸盐综合征是由孕期接触丙戊酸所致。其特征为独特的面部外观、一系列大小不等的畸形以及中枢神经系统功能障碍。在此,我们报告一名患有胎儿丙戊酸盐综合征典型面部特征的4岁男孩。

相似文献

1
Fetal valproate syndrome.胎儿丙戊酸盐综合征
Indian J Pediatr. 2006 Oct;73(10):937-9. doi: 10.1007/BF02859291.
2
Fetal valproate syndrome in a 2-month-old male infant.一名2个月大男婴的胎儿丙戊酸综合征
Ann Saudi Med. 2010 May-Jun;30(3):233-5. doi: 10.4103/0256-4947.62839.
3
Multiple congenital malformations including generalized hypertrichosis with gum hypertrophy in a child exposed to valproic acid in utero.一名在子宫内接触丙戊酸的儿童出现多种先天性畸形,包括全身性多毛症伴牙龈肥大。
Genet Couns. 2003;14(3):289-98.
4
A male with fetal valproate syndrome and autism.一名患有胎儿丙戊酸综合征和自闭症的男性。
Dev Med Child Neurol. 1997 Sep;39(9):632-4. doi: 10.1111/j.1469-8749.1997.tb07500.x.
5
Reduced corneal sensation and severe dry eyes in a child with fetal valproate syndrome.一名患有胎儿丙戊酸盐综合征的儿童出现角膜感觉减退和严重干眼。
Eye (Lond). 2001 Oct;15(Pt 5):661-2. doi: 10.1038/eye.2001.207.
6
[The newborn infant of mothers under treatment with anticonvulsants. Description of 5 cases].[接受抗惊厥药物治疗的母亲所生的新生儿。5例病例描述]
Pediatr Med Chir. 1983 Nov-Dec;5(6):561-70.
7
[Fetal valproate syndrome].
Ryoikibetsu Shokogun Shirizu. 2000(30 Pt 5):96-8.
8
Dysmorphic features: an important clue to the diagnosis and severity of fetal anticonvulsant syndromes.畸形特征:胎儿抗惊厥综合征诊断及严重程度的重要线索。
Arch Dis Child Fetal Neonatal Ed. 2006 Mar;91(2):F90-5. doi: 10.1136/adc.2004.067421. Epub 2005 Oct 20.
9
Lung hypoplasia--a possible teratogenic effect of valproate. Case report.肺发育不全——丙戊酸盐可能的致畸作用。病例报告。
APMIS. 1998 Feb;106(2):300-4. doi: 10.1111/j.1699-0463.1998.tb01350.x.
10
[Hyperammonia, hypoglycemia and thrombocytopenia in a newborn after materanl treatment with valproate].
Arch Pediatr. 2001 Apr;8(4):446-7. doi: 10.1016/s0929-693x(00)00223-2.

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Three Decades of Valproate: A Current Model for Studying Autism Spectrum Disorder.30 年丙戊酸:自闭症谱系障碍的当前研究模型。
Curr Neuropharmacol. 2024;22(2):260-289. doi: 10.2174/1570159X22666231003121513.
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Perinatal Stressors as a Factor in Impairments to Nervous System Development and Functions: Review of In Vivo Models.围产期应激源作为神经系统发育和功能损害的一个因素:体内模型综述
Neurosci Behav Physiol. 2023;53(1):61-69. doi: 10.1007/s11055-023-01391-y. Epub 2023 Mar 11.
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Are female bipolar patients of reproductive age aware of the teratogenic risk of sodium valproate? A qualitative study.

本文引用的文献

1
Fatal cardiac malformation in fetal valproate syndrome.
Indian J Pediatr. 2001 Oct;68(10):989-90. doi: 10.1007/BF02722604.
2
Valproic acid embryopathy: report of two siblings with further expansion of the phenotypic abnormalities and a review of the literature.丙戊酸胚胎病:两例同胞病例报告及表型异常的进一步扩展并文献复习
Am J Med Genet. 2001 Jan 15;98(2):168-75.
3
Anomalous right pulmonary artery origins in association with the fetal valproate syndrome.与胎儿丙戊酸综合征相关的右肺动脉起源异常。
育龄期女性双相情感障碍患者是否知晓丙戊酸钠的致畸风险?一项定性研究。
S Afr J Psychiatr. 2022 Jan 31;28:1719. doi: 10.4102/sajpsychiatry.v28i0.1719. eCollection 2022.
4
Impact of pharmacological agents on mitochondrial function: a growing opportunity?药物对线粒体功能的影响:一个不断增长的机会?
Biochem Soc Trans. 2019 Dec 20;47(6):1757-1772. doi: 10.1042/BST20190280.
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Fetal valproate syndrome.胎儿丙戊酸盐综合征
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5
Evidence for multi-site closure of the neural tube in humans.人类神经管多部位闭合的证据。
Am J Med Genet. 1993 Oct 1;47(5):723-43. doi: 10.1002/ajmg.1320470528.
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Malformations, withdrawal manifestations, and hypoglycaemia after exposure to valproate in utero.子宫内接触丙戊酸盐后的畸形、戒断表现和低血糖。
Arch Dis Child. 1993 Sep;69(3 Spec No):288-91. doi: 10.1136/adc.69.3_spec_no.288.
7
Fetal valproate syndrome: clinical and neuro-developmental features in two sibling pairs.胎儿丙戊酸盐综合征:两对同胞兄妹的临床及神经发育特征
Dev Med Child Neurol. 1994 Apr;36(4):361-9. doi: 10.1111/j.1469-8749.1994.tb11858.x.
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Teratogenicity of valproic acid.
J Pediatr. 1980 Aug;97(2):332-3. doi: 10.1016/s0022-3476(80)80517-8.
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The fetal valproate syndrome.胎儿丙戊酸盐综合征。
Am J Med Genet. 1984 Nov;19(3):473-81. doi: 10.1002/ajmg.1320190308.
10
Valproate, birth defects, and zinc.
Lancet. 1983 Jan 22;1(8317):181. doi: 10.1016/s0140-6736(83)92775-7.