Zenovko E I, Pavlov B A, Koreshkov G G, Gudukina G N, Sonkina E G
Ter Arkh. 1998;70(1):49-52.
Study of the function of the hypothalamus-pituitary-thyroid system in rheumatoid arthritis (RA) MATERIALS AND METHODS: Three hundred and fifty patients with RA of different forms, stages, and intensity were examined. The blood and synovial fluid (SF) levels of thyroid-stimulating hormone (TSH), thyroxine (T4) and triiodothyronine (T3) were measured by immunoradiometric assay.
Patients with RA were found to have higher T4 levels (in articular rheumatism, there was its negative correlation with the intensity of the process and in the presence of systemic manifestations of RA, there was a positive correlation). Blood T5 levels with higher RA intensity tended to increase in patients untreated with glucocorticosteroids. Blood TST concentrations showed an upward tendency which correlated with the intensity and stage of RA. Changes were also revealed in SF TST, T4, T3 levels.
The changes in the secretion of TSH, T4, T3 in patients with RA are caused by this pathological process and those in their SF levels affect the course of articular inflammation.
研究下丘脑 - 垂体 - 甲状腺系统在类风湿关节炎（RA）中的功能
对350例不同类型、阶段和病情严重程度的类风湿关节炎患者进行检查。采用免疫放射分析测定促甲状腺激素（TSH）、甲状腺素（T4）和三碘甲状腺原氨酸（T3）的血液及滑液（SF）水平。
发现类风湿关节炎患者的T4水平较高（在关节型风湿病中，其与病情严重程度呈负相关，而在类风湿关节炎出现全身表现时呈正相关）。未接受糖皮质激素治疗的病情较重的类风湿关节炎患者血液中T5水平有升高趋势。血液中促甲状腺激素浓度呈上升趋势，且与类风湿关节炎的病情严重程度和阶段相关。滑液中促甲状腺激素、T4、T3水平也有变化。
类风湿关节炎患者促甲状腺激素、T4、T3分泌的变化是由该病理过程引起的，其滑液水平的变化影响关节炎症进程。
