Macara L M, Lamont D, Symonds R P
Department of Gynaecology, Western Infirmary, Glasgow.
Scott Med J. 1998 Feb;43(1):16-8. doi: 10.1177/003693309804300105.
A retrospective study was carried out to determine the incidence and nature of second primary malignancies in patients treated for cervical cancer in the West of Scotland. A total of 3911 patients treated for a primary cancer of cervix, diagnosed between 1975 and 1992, were identified from the West of Scotland Cancer Registry. The ratio of observed second primary cancers in the study cohort to the number expected to occur if incidence was the same as in the West of Scotland population as a whole was calculated. Of the 3911 women treated, 129 (3.3%) were diagnosed with a second primary malignancy. Tissues within the pelvic radiation field showed no significant excess of second primary tumours. A significant excess (O/E 2.52 [95% c.i. 1.89-3.30]) of second primary malignancy in the lung and pleura was identified even after correction for socio-economic deprivation. Women treated for cervical cancer in the West of Scotland appear to be at more risk of a subsequent cancer due to causes other than the late effects of radiotherapy.
开展了一项回顾性研究，以确定在苏格兰西部接受宫颈癌治疗的患者中第二原发性恶性肿瘤的发病率和性质。从苏格兰西部癌症登记处确定了1975年至1992年间共3911例接受原发性宫颈癌治疗的患者。计算了研究队列中观察到的第二原发性癌症数量与如果发病率与整个苏格兰西部人群相同预期发生的数量之比。在接受治疗的3911名女性中，有129名（3.3%）被诊断患有第二原发性恶性肿瘤。盆腔放疗区域内的组织未显示第二原发性肿瘤有明显过量。即使在对社会经济剥夺因素进行校正后，仍发现肺和胸膜的第二原发性恶性肿瘤有显著过量（观察值与预期值之比为2.52 [95%可信区间1.89 - 3.30]）。在苏格兰西部接受宫颈癌治疗的女性似乎因放疗晚期效应以外的其他原因而有更高的后续患癌风险。
