Xiaoguang C, Hongyan L, Xiaohong L, Zhaodi F, Yan L, Lihua T, Rui H
Department of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, People's Republic of China.
J Ethnopharmacol. 1998 Feb;60(1):71-8. doi: 10.1016/s0378-8741(97)00133-5.
Red ginseng extract A and B are the active components of Panax ginseng. Red ginseng is a classical traditional Chinese medicine. Among Chinese herbs, red ginseng has been considered as one of the tonics. Many studies indicated that red ginseng could enhance immune function of the human body. The effects of red ginseng extracts on transplantable tumors, proliferation of lymphocyte, two-stage model and rat liver lipid peroxidation were studied. In a two-stage model, red ginseng extracts had a significant cancer chemoprevention. At 50-400 mg/kg, they could inhibit DMBA/Croton oil-induced skin papilloma in mice, decrease the incidence of papilloma, prolong the latent period of tumor occurrence and reduce tumor number per mouse in a dose-dependent manner. Red ginseng extract B could effectively inhibit the Fe2+/cysteine-induced lipid peroxidation of rat liver microsome, suggesting that red ginseng extract B has a stronger antioxidative effect than that of extract A. The results indicated that red ginseng extracts (50 approximately 400 mg/kg) could significantly inhibit the growth of transplantable mouse sarcoma S180 and melanoma B16. Red ginseng extracts A (0.5 mg/ml) and B (0.1 and 0.25 mg/ml) might effectively promote the transformation of T lymphocyte, but there was no influence on lymphocyte proliferation stimulated by concanavalin A. This suggests that red ginseng extracts have potent tumor therapeutic activity and improve the cell immune system.
红参提取物A和B是人参的活性成分。红参是一种经典的传统中药。在中草药中，红参一直被视为滋补品之一。许多研究表明，红参可以增强人体的免疫功能。研究了红参提取物对可移植肿瘤、淋巴细胞增殖、两阶段模型和大鼠肝脏脂质过氧化的影响。在两阶段模型中，红参提取物具有显著的癌症化学预防作用。在50 - 400 mg/kg剂量下，它们可以抑制二甲基苯并蒽/巴豆油诱导的小鼠皮肤乳头瘤，降低乳头瘤的发生率，延长肿瘤发生的潜伏期，并以剂量依赖的方式减少每只小鼠的肿瘤数量。红参提取物B可以有效抑制Fe2+/半胱氨酸诱导的大鼠肝微粒体脂质过氧化，表明红参提取物B具有比提取物A更强的抗氧化作用。结果表明，红参提取物（50约400 mg/kg）可以显著抑制可移植小鼠肉瘤S180和黑色素瘤B16的生长。红参提取物A（0.5 mg/ml）和B（0.1和0.25 mg/ml）可能有效促进T淋巴细胞的转化，但对刀豆球蛋白A刺激的淋巴细胞增殖没有影响。这表明红参提取物具有强大的肿瘤治疗活性并改善细胞免疫系统。
