Fabry W, Okemo P O, Ansorg R
Institut für Medizinische Mikrobiologie, Universitätsklinikum Essen, Germany.
J Ethnopharmacol. 1998 Feb;60(1):79-84. doi: 10.1016/s0378-8741(97)00128-1.
In an ethnopharmacological survey, extracts of the six East African medicinal plants Entada abyssinica (stem bark), Terminalia spinosa (young branches), Harrisonia abyssinica (roots), Ximenia caffra (roots), Azadirachta indica (stem bark and leaves), and Spilanthes mauritiana (roots and flowers) were tested against 105 strains of bacteria from seven genera (Staphylococcus, Enterococcus, Pseudomonas, Escherichia, Klebsiella, Salmonella, Mycobacterium). The minimum inhibitory concentration reached by 50% (MIC50%) and 90% (MIC90) of the strains for the extracts of E. abyssinica, T. spinosa, X. caffra, and A. indica (stem bark) ranged from 0.13-8 mg/ml and from 0.5 to > 8 mg/ml, respectively. Their minimum bactericidal concentration by 50% (MBC50%) and MBC90% were all between 0.5 and > 8 mg/ml. H. abyssinica, A. indica (leaves), and S. mauritiana (roots and flowers) had MIC and MBC values > or = 8 mg/ml. Mycobacteria were not inhibited at extract concentrations of 0.5-2 mg/ml. It is concluded that plant extracts with low MIC and MBC values may serve as sources for compounds with therapeutic potency.
在一项民族药理学调查中，对六种东非药用植物的提取物进行了测试，这些植物分别是：非洲榼藤（茎皮）、多毛诃子（嫩枝）、阿比西尼亚滨枣（根）、南非山梅（根）、印楝（茎皮和叶）以及毛果山金车（根和花），测试对象为来自七个属（葡萄球菌属、肠球菌属、假单胞菌属、大肠杆菌属、克雷伯菌属、沙门氏菌属、分枝杆菌属）的105株细菌。非洲榼藤、多毛诃子、南非山梅和印楝（茎皮）提取物对50%（MIC50%）和90%（MIC90）菌株的最低抑菌浓度分别为0.13 - 8毫克/毫升和0.5至>8毫克/毫升。它们50%（MBC50%）和90%（MBC90%）的最低杀菌浓度均在0.5至>8毫克/毫升之间。阿比西尼亚滨枣、印楝（叶）和毛果山金车（根和花）的MIC和MBC值≥8毫克/毫升。在提取物浓度为0.5 - 2毫克/毫升时，分枝杆菌未受到抑制。得出的结论是，具有低MIC和MBC值的植物提取物可能是具有治疗效力的化合物的来源。
