Zutter M M, Hess J L
Washington University School of Medicine, St Louis, Missouri 63110, USA.
Am J Clin Pathol. 1998 Apr;109(4 Suppl 1):S9-22.
Our progress in understanding and treating pediatric acute leukemia and lymphoma is one of the success stories of cancer biology and management. Event-free survival for children with acute leukemia or lymphoma has improved progressively during the past four decades. The advances in the cell and molecular biology of acute leukemia and lymphoma that have been made can help determine both prognosis and therapy; however, the pathologic evaluation of bone marrow and lymph node specimens must be directed appropriately to benefit from these advances. We present guidelines for the pathologic evaluation of bone marrow and lymph node specimens to maximize the chance that each patient will benefit from our increased understanding of these diseases.
我们在理解和治疗儿童急性白血病及淋巴瘤方面所取得的进展，是癌症生物学与管理领域的成功范例之一。在过去的四十年间，患有急性白血病或淋巴瘤的儿童的无事件生存率逐步提高。急性白血病和淋巴瘤在细胞及分子生物学方面取得的进展有助于确定预后和治疗方案；然而，骨髓和淋巴结标本的病理评估必须合理进行，以便从这些进展中获益。我们提出骨髓和淋巴结标本病理评估的指南，以最大程度地提高每位患者从我们对这些疾病不断加深的认识中获益的机会。
