Marqusee E, Haden S T, Utiger R D
Harvard Medical School, Boston, Massachusetts, USA.
Endocrinol Metab Clin North Am. 1998 Mar;27(1):37-49. doi: 10.1016/s0889-8529(05)70296-6.
Subclinical thyrotoxicosis is defined as low serum thyrotropin (TSH) and normal serum thyroid hormone concentrations. It must be distinguished from nonthyroidal illness and secondary hypothyroidism. The most common causes are excessive thyroid hormone therapy, autonomously functioning thyroid adenoma, multinodular goiter, and Graves' disease, but many patients have no evident thyroid disease. A few patients have minor symptoms and signs of hyperthyroidism. The likelihood of progression to overt thyrotoxicosis is low, and many patients have normal serum TSH concentrations weeks or months later. Treatment should be based on consideration of the cause of the subclinical thyrotoxicosis, and whether the patient has any clinical manifestations of thyroid hormone excess or underlying problems likely to be aggravated by small increases in thyroid secretion.
亚临床甲状腺毒症的定义为血清促甲状腺激素（TSH）降低而血清甲状腺激素浓度正常。必须将其与非甲状腺疾病和继发性甲状腺功能减退相区分。最常见的病因是甲状腺激素治疗过量、自主性功能性甲状腺腺瘤、多结节性甲状腺肿和格雷夫斯病，但许多患者并无明显的甲状腺疾病。少数患者有轻微的甲状腺功能亢进症状和体征。进展为显性甲状腺毒症的可能性较低，许多患者在数周或数月后血清TSH浓度恢复正常。治疗应基于对亚临床甲状腺毒症病因的考虑，以及患者是否有甲状腺激素过量的任何临床表现或可能因甲状腺分泌少量增加而加重的潜在问题。
