Fadel B M, Ellahham S, Ringel M D, Lindsay J, Wartofsky L, Burman K D
Division of Cardiovascular Medicine, Stanford University, California 94305-5406, USA.
Clin Cardiol. 2000 Jun;23(6):402-8. doi: 10.1002/clc.4960230605.
The heart is an organ sensitive to the action of thyroid hormone, and measurable changes in cardiac performance are detected with small variations in thyroid hormone serum concentrations. Most patients with hyperthyroidism experience cardiovascular manifestations, and the most serious complications of hyperthyroidism occur as a result of cardiac involvement. Recent studies provide important insights into the molecular pathways that mediate the action of thyroid hormone on the heart and allow a better understanding of the mechanisms that underlie the hemodynamic and clinical manifestations of hyperthyroidism. Several cardiovascular conditions and drugs can interfere with thyroid hormone levels and may pose a difficulty in interpretation of laboratory data in patients with suspected thyroid heart disease. The focus of this report is a review of the current knowledge of thyroid hormone action on the heart and the clinical and hemodynamic laboratory findings as well as therapeutic management of patients with hyperthyroid heart disease.
心脏是对甲状腺激素作用敏感的器官，甲状腺激素血清浓度的微小变化就能检测到心脏功能的可测量变化。大多数甲状腺功能亢进患者会出现心血管表现，而甲状腺功能亢进最严重的并发症是由心脏受累引起的。最近的研究为介导甲状腺激素对心脏作用的分子途径提供了重要见解，有助于更好地理解甲状腺功能亢进的血流动力学和临床表现的潜在机制。几种心血管疾病和药物会干扰甲状腺激素水平，可能给疑似甲状腺心脏病患者的实验室数据解读带来困难。本报告的重点是回顾目前关于甲状腺激素对心脏作用的知识、临床和血流动力学实验室检查结果以及甲状腺功能亢进性心脏病患者的治疗管理。
