McIver B, Morris J C
Mayo Graduate School of Medicine, Rochester, Minnesota, USA.
Endocrinol Metab Clin North Am. 1998 Mar;27(1):73-89. doi: 10.1016/s0889-8529(05)70299-1.
Graves' disease, one of the autoimmune thyroid diseases, is caused by the production of IgG autoantibodies directed against the thyrotropin receptor. These antibodies bind to and activate the receptor, causing the autonomous production of thyroid hormones. Despite recent improvements in our understanding of the cellular and molecular basis of autoimmunity, our currently available treatments for Graves' disease have remained largely unchanged over the last 50 years. Nevertheless, new concepts in immune system regulation hold out the prospect in the future for intervention designed to modify, and possibly cure, the underlying disease process.
格雷夫斯病是自身免疫性甲状腺疾病之一，由针对促甲状腺激素受体的IgG自身抗体产生所致。这些抗体与受体结合并激活受体，导致甲状腺激素自主产生。尽管我们对自身免疫的细胞和分子基础的理解最近有所进步，但在过去50年里，我们目前可用的格雷夫斯病治疗方法基本没有变化。然而，免疫系统调节的新概念为未来旨在改变并可能治愈潜在疾病进程的干预措施带来了希望。
