在家庭环境中口服阿昔洛韦进行水痘暴露后预防后保护性免疫的持久性。
Persistence of protective immunity after postexposure prophylaxis of varicella with oral aciclovir in the family setting.
作者信息
Yoshikawa T, Suga S, Kozawa T, Kawaguchi S, Asano Y
机构信息
Department of Paediatrics, Fujita Health University, School of Medicine, Aichi, Japan.
出版信息
Arch Dis Child. 1998 Jan;78(1):61-3. doi: 10.1136/adc.78.1.61.
The persistence of protective immunity after postexposure prophylaxis against varicella using oral aciclovir was evaluated in the family setting. Sixty one of 78 recipients of oral aciclovir were assessed by questionnaire, and 13 of 61 were evaluated for serum antibody to varicella zoster virus (VZV) using the fluorescent antibody to membrane antigen method. The observation period ranged from 33 to 50 months. None of those (n = 44) who had initially seroconverted to VZV after aciclovir prophylaxis developed breakthrough varicella. All 13 who had serology repeated still had titres > or = 4. Antibody titres in those who had histories of re-exposure to the virus were significantly higher than in those who had not (p < 0.01).
在家庭环境中评估了口服阿昔洛韦进行水痘暴露后预防后保护性免疫的持久性。通过问卷调查对78名口服阿昔洛韦的接受者中的61名进行了评估，并使用膜抗原荧光抗体法对61名中的13名进行了水痘带状疱疹病毒（VZV）血清抗体评估。观察期为33至50个月。在阿昔洛韦预防后最初血清转化为VZV的那些人（n = 44）中，没有一人发生突破性水痘。重复进行血清学检测的所有13人其滴度仍≥4。有病毒再次暴露史的人的抗体滴度显著高于没有再次暴露史的人（p < 0.01）。
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