Robben J H, Mout H C, Kuijpers E A
Intensieve Zorg Afdeling, Faculteit der Diergeneeskunde, Universiteit Utrecht.
Tijdschr Diergeneeskd. 1997 Sep 1;122(17):466-71.
The occurrence, the diagnosis, and the treatment of anticoagulant rodenticide poisoning in dogs in the Netherlands was evaluated by a survey among Dutch veterinarians carried out by the National Poisons Control Center (NPCC). The survey included information on 54 dogs, 32 being treated by veterinarians who consulted the NPCC and 22 that were admitted to the Utrecht University Clinic for Companion Animals (UUCCA). The poisons that were suspected were brodifacoum (n = 19), bromadiolone (n = 14), difenacoum (n = 8), difethialone (n = 6) and chlorophacinone (n = 1). In 6 dogs the identity of the poison was unknown. Of 31 dogs with hemorrhages, 2 died shortly after presentation to practitioners and 2 died shortly after admission to the UUCCA. Signs of bleeding occurred especially in poisoning by brodifacoum (n = 16). In all but one of the dogs without hemorrhages, the intake of poison had taken place within 24 hours before presentation. The method of treatment varied, with the induction of vomiting and the use of vitamin K mentioned most. The choice of therapy was determined by the length of time after intake of the poison, the clinical signs and whether or not an anticoagulant toxicosis was suspected at the time of the initial examination. These findings provide the basis for discussion of several aspects of diagnosis and treatment.
荷兰国家毒物控制中心(NPCC)通过对荷兰兽医进行的一项调查,评估了荷兰犬类抗凝血灭鼠剂中毒的发生情况、诊断和治疗。该调查涵盖了54只犬的信息,其中32只由咨询NPCC的兽医进行治疗,22只被送往乌得勒支大学伴侣动物诊所(UUCCA)。疑似中毒的毒物有溴敌隆(n = 19)、溴鼠灵(n = 14)、敌鼠酮(n = 8)、杀鼠醚(n = 6)和氯鼠酮(n = 1)。6只犬的毒物种类不明。在31只出现出血症状的犬中,2只在就诊后不久死亡,2只在进入UUCCA后不久死亡。出血症状尤其在溴敌隆中毒(n = 16)时出现。在除1只犬外的所有无出血症状的犬中,中毒发生在就诊前24小时内。治疗方法各不相同,最常提及的是催吐和使用维生素K。治疗方法的选择取决于中毒后经过的时间、临床症状以及初次检查时是否怀疑有抗凝血中毒。这些发现为讨论诊断和治疗的几个方面提供了依据。