Sucato G, Wald A, Wakabayashi E, Vieira J, Corey L
Department of Pediatrics, University of Washington, Seattle 98122, USA.
J Infect Dis. 1998 Apr;177(4):1069-72. doi: 10.1086/515261.
While superinfection with different herpes simplex virus (HSV) types has been demonstrated in animals, the ability of the two HSV types to colonize and reactivate in the same anatomic region in humans has not been well demonstrated. In 6 patients, both HSV-1 and HSV-2 was recovered from genital lesions. In 4 of them, who initially acquired genital HSV-1 infection, subsequent HSV-2 infection presented as a prolonged episode of genital lesions and a marked increase in the frequency of genital recurrences. While most of the subsequent clinical reactivations were HSV-2, in 2 patients the recurrence rate of genital HSV-1 increased after the acquisition of HSV-2. These data demonstrate the ability of a second HSV type to infect the same anatomic region and illustrate the difference in reactivation frequency of the two types in the same person. Typing of HSV isolates may be useful in persons with recent alteration in recurrence rates of genital HSV.
虽然在动物中已证实存在不同类型单纯疱疹病毒（HSV）的重叠感染，但两种HSV类型在人类同一解剖区域定植和再激活的能力尚未得到充分证实。在6例患者中，从生殖器病变中分离出了HSV-1和HSV-2。其中4例最初感染生殖器HSV-1，随后的HSV-2感染表现为生殖器病变的持续发作以及生殖器复发频率显著增加。虽然大多数后续临床再激活是由HSV-2引起的，但在2例患者中，感染HSV-2后生殖器HSV-1的复发率增加。这些数据证明了第二种HSV类型感染同一解剖区域的能力，并说明了同一人两种类型再激活频率的差异。对HSV分离株进行分型可能对近期生殖器HSV复发率发生改变的患者有用。
