Abdel-Gawad F M
National Organization for Drug Control and Research, Cairo, Egypt.
J Pharm Biomed Anal. 1998 Jan;16(5):793-9. doi: 10.1016/s0731-7085(97)00123-4.
A systematic spectrophotometric study on the ion-pair formation of Bi(III)-iodide with amineptine hydrochloride, piribedil and trimebutine maleate is carried out. The optimal experimental conditions pH, concentration of Bi(III) nitrate, potassium iodide; and the nature and amount of organic solvent have been studied. The ion pairs are soluble in 1,2-dichloroethane and the optimum pH range is 2.0-2.8. By application of the methods of Sommer and Job involving non-equimolar solutions, the conditional stability constant (log K') of the Bi(III) piridedil ion pair (1:1) at the optimum pH of 2.4 and an ionic strength (mu) 0.1 M, was found to be 5.436. The validity of Beer's law has been tested in the concentration range 5-50 microg ml(-1) in the organic layer, the relative standard deviation is less than 1%. The method is applied to the determination of these drugs in tablets without interference.
对盐酸阿密替林、匹立哌唑和马来酸曲美布汀与碘化铋（III）形成离子对进行了系统的分光光度研究。研究了最佳实验条件，即pH值、硝酸铋（III）浓度、碘化钾浓度以及有机溶剂的性质和用量。离子对可溶于1,2 - 二氯乙烷，最佳pH范围为2.0 - 2.8。通过应用涉及非等摩尔溶液的索末尔法和乔布法，发现在最佳pH值2.4和离子强度（μ）0.1 M时，铋（III）匹立哌唑离子对（1:1）的条件稳定常数（log K'）为5.436。在有机层中5 - 50 μg ml⁻¹的浓度范围内对朗伯 - 比尔定律的有效性进行了测试，相对标准偏差小于1%。该方法用于片剂中这些药物的测定，无干扰。
