Basu D, Mahalanabis K K, Roy B
Department of Chemistry, Jadavpur University, Calcutta, India.
J Pharm Biomed Anal. 1998 Jan;16(5):809-12. doi: 10.1016/s0731-7085(97)00111-8.
Least squares method in matrix form which is K-matrix representation of Beer's law is presented for simultaneous determination of ibuprofen and paracetamol in tablets without prior separation from each other. The concentration of each component in the mixture was determined spectrophotometrically from absorbances of the mixture measured at 225, 226, 228, 232, 230, 234, and 235 nm. Mixtures of known composition were used as standards to minimise errors due to presence of both compounds in the same solution. Excellent results were obtained by this method.
提出了以矩阵形式表示的最小二乘法，即比尔定律的K矩阵表示法，用于不经预先分离同时测定片剂中的布洛芬和对乙酰氨基酚。通过在225、226、228、232、230、234和235 nm处测量混合物的吸光度，用分光光度法测定混合物中各组分的浓度。使用已知组成的混合物作为标准，以尽量减少由于两种化合物存在于同一溶液中而产生的误差。该方法获得了优异的结果。
