Cahill C A
MGH Institute of Health Professions, Boston, MA 02114, USA.
Nurs Res. 1998 Sep-Oct;47(5):278-84. doi: 10.1097/00006199-199809000-00007.
A significant number of American women of childbearing age are troubled by premenstrual symptoms, but the underlying cause is not understood, resulting in inadequate therapy.
To use basal levels of cortisol to differentiate women with low symptom (LS) patterns of turmoil-type premenstrual symptoms from women with premenstrual symptom (PMS) patterns and from women with premenstrual magnification (PMM) patterns of turmoil-type premenstrual symptoms.
Symptom and cortisol patterns of women were monitored for three consecutive menstrual cycles. Three distinct groups of women were identified based on symptom patterns and types.
Significant differences in symptom severity among groups were observed during the follicular (F = 203; df= 2, 24; p < .0001) and luteal phases (F= 51.3; df= 2, 24; p< .0001) of the cycle. There were no statistically significant differences in cortisol among groups for the follicular phase, but there were during the luteal phase (F= 4.0; df= 2, 24; p= .03).
Altered regulation of the stress axis may be involved in mediating turmoil-type PMS.
大量美国育龄妇女受经前症状困扰，但潜在病因不明，导致治疗不足。
利用皮质醇基础水平区分具有低症状（LS）模式的动荡型经前症状女性与经前症状（PMS）模式女性以及具有经前放大（PMM）模式的动荡型经前症状女性。
连续三个月经周期监测女性的症状和皮质醇模式。根据症状模式和类型确定了三组不同的女性。
在月经周期的卵泡期（F = 203；自由度 = 2, 24；p <.0001）和黄体期（F = 51.3；自由度 = 2, 24；p <.0001）观察到组间症状严重程度存在显著差异。卵泡期各组间皮质醇无统计学显著差异，但黄体期存在差异（F = 4.0；自由度 = 2, 24；p =.03）。
应激轴调节改变可能参与介导动荡型经前综合征。
