Hjollund N H, Bonde J P, Jensen T K, Ernst E, Henriksen T B, Kolstad H A, Giwercman A, Skakkebaek N E, Olsen J
Department of Occupational Medicine, Aarhus University Hospital, Denmark.
Reprod Toxicol. 1998 Mar-Apr;12(2):91-5. doi: 10.1016/s0890-6238(97)00156-1.
Welding may involve hazards to the male reproductive system, but previous studies of semen quality have produced inconsistent results. We studied the effects of welding on markers of semen quality in a Danish nationwide sample of 430 first-time pregnancy planners without earlier reproductive experience. Couples were recruited among members of the union of metal workers and three other trade unions and were followed from termination of birth control until pregnancy for a maximum of six menstrual cycles. The males provided semen samples in each cycle. Median sperm density for welders was 56 x 10(6)/mL (52.5 x 10(6)/mL and 50.0 x 10(6)/mL in two reference groups). No statistically significant differences attributable to welding were found in proportions of morphologically normal sperm, sperm motility assessed by computer-aided sperm analysis, or sex hormones (testosterone, follicle-stimulating hormone, and luteinizing hormone). These negative findings may not apply to populations with high-level exposure to welding fume or to welders exposed to other putative hazards, e.g., heat.
焊接可能对男性生殖系统有危害，但先前关于精液质量的研究结果并不一致。我们在丹麦全国范围内对430名无早期生殖经历的首次怀孕计划者进行了抽样研究，以探讨焊接对精液质量指标的影响。研究对象从金属工人联盟及其他三个工会的成员中招募，从停止避孕开始跟踪至怀孕，最长跟踪六个月经周期。男性在每个周期都提供精液样本。焊工的精子密度中位数为56×10⁶/mL（两个参照组分别为52.5×10⁶/mL和50.0×10⁶/mL）。在形态正常精子的比例、通过计算机辅助精子分析评估的精子活力或性激素（睾酮、促卵泡激素和促黄体生成素）方面，未发现因焊接导致的具有统计学意义的差异。这些阴性结果可能不适用于高浓度接触焊接烟尘的人群，也不适用于接触其他假定危害（如高温）的焊工。
