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如何在实验毒理学中优化计算机辅助精子分析的效益。

How to optimize the benefits of computer assisted sperm analysis in experimental toxicology.

机构信息

Department of in vivo Pharmacology / Toxicology, BSL BIOSERVICE Scientific Laboratories GmbH, Behringstr, 6 / 8, Planegg/Munich 82152, Germany.

出版信息

J Occup Med Toxicol. 2013 Mar 11;8(1):6. doi: 10.1186/1745-6673-8-6.

DOI:10.1186/1745-6673-8-6
PMID:23497634
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3599994/
Abstract

Exposure at the working place to various substances, that may affect semen quality is possible and should be investigated in detail. One appropriate method for this is computer-assisted sperm analysis (CASA) which offers multiple benefits in comparison to manual evaluation. However, several pitfalls exist, which make the evaluation of data obtained from CASA difficult to interpret. In the present commentary, we focus on these problems, show some examples, and try to define minimum standards which should be taken into consideration whenever working with computer-assisted sperm analysis.

摘要

工作场所接触各种可能影响精液质量的物质是有可能的，应该进行详细调查。一种合适的方法是计算机辅助精子分析（CASA），与手动评估相比，它具有多种优势。然而，存在一些缺陷，使得对 CASA 获得的数据进行评估变得难以解释。在本评论中，我们重点关注这些问题，展示一些示例，并尝试定义在使用计算机辅助精子分析时应考虑的最低标准。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb7c/3599994/f90772de8248/1745-6673-8-6-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb7c/3599994/6a8ed22fd60f/1745-6673-8-6-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb7c/3599994/f90772de8248/1745-6673-8-6-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb7c/3599994/6a8ed22fd60f/1745-6673-8-6-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb7c/3599994/f90772de8248/1745-6673-8-6-2.jpg

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Nanoparticles and spermatogenesis: how do nanoparticles affect spermatogenesis and penetrate the blood-testis barrier.纳米颗粒与精子发生：纳米颗粒如何影响精子发生并穿透血睾屏障。
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肺部的纳米颗粒。
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Semen quality and sex hormones with reference to metal welding.精液质量和性激素与金属焊接的关系
Reprod Toxicol. 1998 Mar-Apr;12(2):91-5. doi: 10.1016/s0890-6238(97)00156-1.
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Fertil Steril. 1994 Dec;62(6):1277-82.