Mehaffey M G, Folberg R, Meyer M, Bentler S E, Hwang T, Woolson R, Moore K C
Department of Ophthalmology, University of Iowa, Iowa City 52242-1182, USA.
Am J Ophthalmol. 1997 Jun;123(6):798-809. doi: 10.1016/s0002-9394(14)71129-8.
To test whether the cross-sectional area of choroidal and ciliary body melanomas and quantification of microcirculatory networks and parallel vessels with cross-linking are features associated with death from metastatic melanoma, and to compare new with conventional histologic prognostic features.
The cross-sectional area of 234 ciliary body or choroidal melanomas was measured from digitized images of histologic sections. The percentage of cross-sectional area occupied by two microcirculatory patterns-networks and parallel vessels with cross-linking-was calculated for the 152 tumors containing at least one focus of either pattern. Kaplan-Meier survival curves were generated based on cross-sectional and percentage of cross-sectional areas of these patterns. Cox proportional hazard regression methods related time to death from melanoma with sets of predictor variables. For each model, percent variation explained was computed.
Patient survival differs significantly when tumors are classified based on cross-sectional area: small (<16 mm2), medium (> or =16 mm2 but <61.4 mm2), and large (> or =61.4 mm2). Patients with tumors containing networks and parallel vessels with cross-linking microcirculation patterns that occupy 2% of cross-sectional area have a significantly worse prognosis than do those patients with tumors containing a smaller percentage of these patterns.
Quantifying cross-sectional tumor area and the percentage area occupied by networks and parallel vessels with cross-linking microcirculatory patterns in ciliary body and cho. roidal melanomas provides significant prognostic information. Compared with more conventional prognostic characteristics, the most dramatic increase in prognostic information is provided by determination of the presence or absence of microvascular patterns.
检测脉络膜和睫状体黑色素瘤的横截面积以及对微循环网络和平行血管交联的量化是否为与转移性黑色素瘤死亡相关的特征，并比较新的组织学预后特征与传统的组织学预后特征。
从组织学切片的数字化图像中测量234例睫状体或脉络膜黑色素瘤的横截面积。对于152例至少含有一种上述模式病灶的肿瘤，计算两种微循环模式（网络和平行血管交联）所占横截面积的百分比。基于这些模式的横截面积及其百分比生成Kaplan-Meier生存曲线。Cox比例风险回归方法将黑色素瘤死亡时间与预测变量集相关联。对于每个模型，计算解释的变异百分比。
根据横截面积对肿瘤进行分类时（小[<16平方毫米]、中[≥16平方毫米但<61.4平方毫米]、大[≥61.4平方毫米]），患者生存率有显著差异。肿瘤含有占横截面积2%的网络和平行血管交联微循环模式的患者，其预后明显比肿瘤含有较小比例这些模式的患者差。
量化睫状体和脉络膜黑色素瘤的肿瘤横截面积以及网络和平行血管交联微循环模式所占的面积百分比可提供重要的预后信息。与更传统的预后特征相比，微血管模式的有无测定能提供最显著增加的预后信息。
