Mehaffey M G, Gardner L M, Folberg R
Department of Ophthalmology and Visual Sciences, University of Iowa, Iowa City 52242-1182, USA.
Am J Ophthalmol. 1998 Sep;126(3):373-8. doi: 10.1016/s0002-9394(98)00092-0.
To investigate the validity of assigning patients whose eyes have been removed for ciliary body or choroidal melanoma to risk groups for metastasis based on the identification of microcirculatory patterns in one cross-section taken from the center of the tumor.
Multiple levels were cut through the blocks of 15 ciliary body or choroidal melanomas until the tumor was exhausted. Each level was examined for the presence of microvascular networks and parallel vessels with cross-linking histologic features strongly associated with death from metastatic melanoma.
The central histologic section did not contain either microvascular networks or parallel vessels with cross-linking in eight tumors, nor were these patterns encountered in any of the more peripheral levels of the tumor. Seven tumors contained at least one focus of either microvascular networks or parallel vessels with cross-linking in the central histologic section. In two tumors, at least one of these patterns appeared in all histologic levels; in five tumors, at least one of these patterns appeared through multiple levels until just before the tumor was exhausted from the block (0.24 to 0.85 mm from the edge of the tumor).
This study suggests that the prognostic classification of uveal melanoma based on the histologic profile of the microcirculation may be consistent throughout the tumor depth.
基于对取自肿瘤中心的一个横截面中微循环模式的识别，研究将因睫状体或脉络膜黑色素瘤而摘除眼球的患者分配到转移风险组的有效性。
对15例睫状体或脉络膜黑色素瘤的组织块进行多层切片，直至肿瘤全部切完。检查每一层是否存在微血管网络和平行血管，这些血管具有与转移性黑色素瘤死亡密切相关的交联组织学特征。
在8个肿瘤中，中央组织学切片既没有微血管网络也没有交联的平行血管，在肿瘤的任何更外周层面也未发现这些模式。7个肿瘤在中央组织学切片中至少有一个微血管网络或交联平行血管的病灶。在2个肿瘤中，这些模式中的至少一种出现在所有组织学层面；在5个肿瘤中，这些模式中的至少一种出现在多个层面，直到肿瘤从组织块中切完前（距肿瘤边缘0.24至0.85毫米）。
本研究表明，基于微循环组织学特征的葡萄膜黑色素瘤预后分类在整个肿瘤深度可能是一致的。
