Murthy K R, Zare M A
Department of Physiology, Seth G S Medical College, Parel, Mumbai, India.
Indian J Exp Biol. 1998 Jan;36(1):16-21.
Acute myocarditis was induced in dogs and rabbits by injection of scorpion (M. tamulus concanesis, earlier called Buthus tamulus) venom by s.c., i.m. or i.v. routes. A decrease in thyroxine (T4) levels was observed following i.v. injection of venom in dogs. In rabbits the venom (i.m.) did not elicit any change in T4 levels. Envenomation (s.c.) resulted in a reduction in triiodothyronine (T3) levels in dogs. Venom injection (s.c.) along with i.v. administration of the species specific antivenom (AScVS) did not cause any change in T3 and T4 levels in general. However an increase in T3 levels following AScVS was observed in envenomated dogs. The results suggest that scorpion envenomation caused an autonomic storm releasing massive amounts of catecholamines, angiotensin II, suppressed insulin secretion and reduced circulating T4 and T3 levels. Decrease in thyroid hormones results in fall in body temperature. Changes in the body temperature may increase the sensitivity of the scorpion venom and influence the course of toxicity.
通过皮下、肌肉内或静脉内注射蝎子（M. tamulus concanesis，先前称为Buthus tamulus）毒液，在犬和兔中诱导急性心肌炎。静脉内注射毒液后，在犬中观察到甲状腺素（T4）水平降低。在兔中，毒液（肌肉内注射）未引起T4水平的任何变化。皮下注射毒液导致犬中三碘甲状腺原氨酸（T3）水平降低。皮下注射毒液并同时静脉内给予物种特异性抗蛇毒血清（AScVS）通常不会引起T3和T4水平的任何变化。然而，在中毒犬中观察到AScVS后T3水平升高。结果表明，蝎子中毒引发自主神经风暴，释放大量儿茶酚胺、血管紧张素II，抑制胰岛素分泌并降低循环T4和T3水平。甲状腺激素减少导致体温下降。体温变化可能会增加蝎子毒液的敏感性并影响毒性进程。
