Kendler K S, Weitzman R E, Fisher D A
Clin Endocrinol (Oxf). 1978 Feb;8(2):89-94. doi: 10.1111/j.1365-2265.1978.tb02156.x.
The effect of pain on plasma AVP concentration in man has previously been studied only during major surgery with general anaesthesia. Plasma AVP concentration (pAVP) and plasma osmolality (pOsm) were measured in thirty-six patients seen in a surgical emergency department complaining of pain and in fifty-one control subjects. No significant difference in pOsm was found, but pAVP was significantly higher in the emergency room patients in pain (M +/- SEM = 4.94 +/- 0.98 pmol/1 compared to 2.31 +/- 0.32 pmol/1 in control subjects, P less than 0.01). In the control subjects, age was found to have a low but significant inverse correlation with pAVP (r = 0.37, P less than 0.01). Chronic smoking was associated with significant elevation of pAVP (3.81 +/- 0.99 pmol/1 in smokers vs. 1.89 +/- 0.28 pmol/1 in non-smokers, P less than 0.02). Neither smoking nor age could account for the difference in pAVP between the pain and control groups. Thus, pain is a non-osmolar factor capable of elevating AVP in conscious man.
此前，疼痛对人体血浆抗利尿激素（AVP）浓度的影响仅在全身麻醉的大手术期间进行过研究。对36名因疼痛到外科急诊就诊的患者和51名对照者测量了血浆AVP浓度（pAVP）和血浆渗透压（pOsm）。pOsm未发现显著差异，但疼痛的急诊患者pAVP显著更高（平均值±标准误=4.94±0.98pmol/L，而对照者为2.31±0.32pmol/L，P<0.01）。在对照者中，年龄与pAVP呈低但显著的负相关（r=0.37，P<0.01）。长期吸烟与pAVP显著升高有关（吸烟者为3.81±0.99pmol/L，非吸烟者为1.89±0.28pmol/L，P<0.02）。吸烟和年龄均不能解释疼痛组与对照组之间pAVP的差异。因此，疼痛是一种能够使清醒人体AVP升高的非渗透压因素。
