患有视网膜病变的糖尿病青少年及青年中的脂质与脂蛋白

Lipids and lipoproteins in diabetic adolescents and young adults with retinopathy.

作者信息

Verrotti A, Lobefalo L, Chiarelli F, Mastropasqua L, Pallotta R, Colangelo L, Morgese G, Gallenga P E

机构信息

Department of Paediatrics, University of Chieti, Italy.

出版信息

Eye (Lond). 1997;11 ( Pt 6):876-81. doi: 10.1038/eye.1997.225.

DOI:10.1038/eye.1997.225

PMID:9537151

Abstract

PURPOSE

To compare serum concentrations of lipoproteins and apolipoproteins in insulin-dependent diabetic patients with and without retinopathy.

METHODS

A cross-sectional study was performed on 42 diabetic adolescents and young adults with different degrees of retinopathy. The mean +/- SD age of the patient was 21.1 years (range 12.8-27.9 years); their mean duration of diabetes was 12.3 years (range 7.1-19.9 years). Their glycosylated haemoglobin (HbA1c) and fructosamine were respectively 10.2% (8.2-15.4%) and 280.8 mumol/l (202.1-458.5 mumol/l). Forty-two diabetics without retinopathy similar to the study population as regards age, sex, duration of disease, HbA1c and microalbuminuria values, and 42 healthy subjects, served as controls.

RESULTS

Serum lipid and lipoprotein concentrations were not different from those of healthy controls in patients either with or without retinopathy. The diabetic patients were subdivided in two groups according to the degree of their retinopathy: background and preproliferative/proliferative retinopathy. Patients with preproliferative/proliferative retinopathy were found to have significantly higher lipoprotein (a) values than the other group (background, 73.3 IU/l; preproliferative/proliferative, 205.9 IU/l; p < 0.001).

CONCLUSION

The increase in lipoprotein (a) levels might play a role in the development of severe retinopathy.

摘要

目的

比较有视网膜病变和无视网膜病变的胰岛素依赖型糖尿病患者的血清脂蛋白和载脂蛋白浓度。

方法

对42例患有不同程度视网膜病变的糖尿病青少年和青年进行了一项横断面研究。患者的平均年龄±标准差为21.1岁（范围12.8 - 27.9岁）；他们的平均糖尿病病程为12.3年（范围7.1 - 19.9年）。他们的糖化血红蛋白（HbA1c）和果糖胺分别为10.2%（8.2 - 15.4%）和280.8μmol/l（202.1 - 458.5μmol/l）。42例无视网膜病变的糖尿病患者，在年龄、性别、病程、HbA1c和微量白蛋白尿值方面与研究人群相似，以及42例健康受试者作为对照。

结果

有视网膜病变和无视网膜病变的患者血清脂质和脂蛋白浓度与健康对照组无差异。糖尿病患者根据其视网膜病变程度分为两组：背景性和增殖前期/增殖性视网膜病变。发现增殖前期/增殖性视网膜病变患者的脂蛋白（a）值显著高于另一组（背景性，73.3 IU/l；增殖前期/增殖性，205.9 IU/l；p < 0.001）。