Shito M, Ueda M, Wakabayashi G, Endo M, Kitajima M
Department of Surgery, Keio University School of Medicine, Tokyo, Japan.
Eur J Surg. 1998 Feb;164(2):115-8. doi: 10.1080/110241598750004760.
To investigate the involvement of vasoactive agents, endothelin (ET)-1, and atrial natriuretic peptide (ANP), and the responses of cytokines in patients undergoing total gastrectomy.
Prospective study.
University hospital, Japan.
20 patients with advanced gastric cancer who had undergone total gastrectomy with lymph node dissection.
Serum or plasma samples collected on the day before the operation, at the time of skin closure, and on postoperative days 1, 3, 5, and 7.
Concentrations of acute phase reactants, cytokines (interleukin (IL)-1, tumour necrosis factor (TNF) and interleukin (IL)-6), and vasoactive agents (ET-1 and ANP).
There were significant increases in concentrations of IL-6 and acute phase reactants postoperatively. ET-1 and ANP concentrations did not change significantly.
There was no correlation between concentrations of the vasoactive agents ET-1 and ANP, and those of acute phase reactants or cytokines in serum or plasma in patients undergoing total gastrectomy.
