Graber J H, O'Donnell M J, Smith C L, Cantor C R
Center for Advanced Biotechnology, Boston University, MA 02215, USA.
Curr Opin Biotechnol. 1998 Feb;9(1):14-8. doi: 10.1016/s0958-1669(98)80078-5.
The key advances in DNA diagnostics during the past year are techniques which will lead to advanced throughput without sacrificing sensitivity: miniaturization of samples to reduce material cost and preparation time, and parallelization through use of measurement arrays. The most promising gains have come in the areas of DNA arrays and mass spectrometry, where differential sequencing measurements are now possible.
过去一年中，DNA诊断技术的关键进展在于，这些技术在不牺牲灵敏度的前提下，能够实现高通量：将样本小型化以降低材料成本和制备时间，并通过使用测量阵列实现并行化。最有前景的进展出现在DNA阵列和质谱领域，现在已经可以进行差异测序测量。
